CONTENTS 



CHAPTER I 



INTRODUCTION 



Bacteria are particulate proteins; all true proteins contain a poi- 

 sonous group ; the chemical nucleus contains the poison ; when proteins 

 are disrupted the poisonous group may be set free; the patho- 

 genicity of a bacterium is not determined by its capability of forming 

 a poison, but is dsterminsd by its ability to grow and multiply 

 in the animal body; any foreign protein which can grow and mul- 

 tiply in the body of a given animal is pathogenic to that animal; 

 the infectious diseases result from the parenteral digestion of proteins; 

 natural bacterial immunity, that which follows an infectious disease, 

 and that induced by vaccination, result from inability of the organ- 

 ism to grow and multiply in the animal body; protein sensitization 

 and bacterial immunity, apparently antipodal, are in reality identical; 

 protein sensitization consists in the development of a new function 

 in certain body cells that of elaborating a specific, proteolytic 

 ferment; a foreign protein introduced into the blood is distributed 

 through the tissues; vaccines are protein sensitizers; toxin and 

 bacterial immunities are different; the protein poison is not a toxin; 

 it is not specific; it elaborates no antibody; it develops a specific 

 ferment; different proteins tend to accumulate in predilection places; 

 the symptoms of the infectious diseases are largely determined by the 

 organ or tissues in which the foreign protein accumulates; the poison 

 elaborated in all the infectious diseases is the same; when a cell in 

 the animal body is permeated by a foreign protein, the former strives 

 to elaborate a ferment by which the latter is destroyed; this we 

 believe to be a biological law . 18 



CHAPTER II 



THE GROWTH OF MASSIVE CULTURES OF BACTERIA 

 The large tanks and the preparation of bacterial cellular substances 29 



