120 



PROTEIN POISONS 



during this period that individual resistance and acquired 

 immunity are important factors acting by causing increased 

 bacteriolysis and the destruction of all bacilli before a 

 fatal dose of poison has been set free. During this time 

 the temperature of the animal may rise to a greater or less 

 extent or may remain stationary; the animal remains 

 active, eats; its coat is not roughened and it appears in 



FIG. 5 



102 

 101 

 100 



\ 



\ 



Temperature curve of guinea-pig after inoculation with 1 c.c., sixteen- 

 hour bouillon culture of the colon bacillus. Death occurred twenty hours 

 after inoculation. 



all respects as well as a normal animal. At the end of this 

 period, however, the appearance changes. The animal 

 becomes less active. It remains in one corner of its cage; 

 its coat becomes roughened; it hangs its head and apparently 

 enters into a state of stupor. At the same time the rectal 

 temperature begins to fall abruptly, as can be seen from 

 a study of Fig. 5. 



