124 



PROTEIN POISONS 



Accompanying the fall in temperature there is apparent 

 lassitude, stupor, and roughening of the coat. In cases in 

 which many times the fatal dose has been given, the animals 

 occasionally die within from four to six hours with convul- 

 sions, a feature which can now and then be observed after 

 the injection of large quantities of the living bacillus. At 

 autopsy we find a picture similar in all respects to that 

 following inoculation with the living colon bacillus. There 

 is a marked hemorrhagic peritonitis, the peritoneal cavity 



FIG. 6 



101 



100 



97 



95 



7 



Temperature curve of guinea-pig after intraperitoneal injection of 

 non-fatal dose of crude bacterial cell substance. 



containing bloody fluid, together with unabsorbed bacterial 

 cell substance, and the omentum and mesentery showing 

 numerous punctiform hemorrhages. It is needless to 

 state that in all cases cultures were made from the peritoneal 

 cavity and heart's blood immediately after death, and 

 these proved to be sterile. From this we see that practically 

 the sole difference between the effects following inoculation 

 with the living bacillus and the injection of the dead bac- 

 terial substance is a shortening of the period of incubation 



