132 



PROTEIN POISONS 



in about the same length of time as in the case of animals 

 treated intraperitoneally. Thus a dose of 180 mgs. always 

 proved fatal in from one-half to three-quarters of an hour. 

 The symptoms are practically identical with those following 

 the intraperitoneal injection with the exception of the fact 

 that the various stages are much more sharply defined. 

 For example, the stage of peripheral irritation is much more 

 marked. The animal soon after injection becomes very 

 restless, runs around his cage, and scratches his body. 

 This itching seems, however, to be general from the outset, 

 and is not, apparently, more pronounced in the immediate 



Z 2? 



FIG. 7 



2 g g g S 



i i i g i f i 



I 



Temperature curve of guinea-pig treated with 45 mgs. of the soluble 

 poison intraperitoneally. 



neighborhood of the site of injection. If the animal has 

 been injected under the skin of the abdomen, its attention 

 is not necessarily first attracted to this spot, but it may 

 begin by scratching its nose or one of the extremities. 

 Another peculiar symptom, which is probably due to 

 peripheral irritation, and which is seldom seen in cases of 

 intraperitoneal injection, is the tendency which the animals 

 show to dig furiously in the shavings in the bottom of their 

 cages. This feature is quite characteristic, and is seldom 

 absent in pigs which have been treated subcutaneously. 

 The later stages are similar in all respects to those seen 

 following the intraperitoneal injection. The animal shows 



