PROTEIN SENSITIZATION OR ANAPHYLAXIS 285 



bacterium is determined by its capability of growing in 

 and ultimately sensitizing the animal body. Furthermore, 

 we demonstrated, to our own satisfaction at least, that the 

 symptoms and lesions of the infections are not directly 

 due to the multiplication of the bacteria in the body, but 

 to their destruction by the sensitized cells of the animal 

 body, because at the time when the growth and multipli- 

 cation of the bacteria proceed most rapidly in the period 

 of incubation there are no symptoms and no lesions. The 

 onset of the disease marks the time when sensitization 

 becomes manifest. 



We found the protein poison in diverse animal and vege- 

 table proteins, and with the few substances in which we 

 did not find the protein poison, such as gelatin and some 

 peptones, we were not able to sensitize guinea-pigs. 



The reasons we have for holding that our protein poison 

 is identical with the anaphylactic poison may be stated 

 as follows: 



1. The protein poison exists in all true proteins, so far 

 as they have been tested, consequently it exists in all 

 anaphylactogens. 



2. Whatever the protein from which the poison is obtained, 

 its physiological action is the same. While there may be 

 and probably are chemical differences in the protein poison 

 as obtained from diverse proteins, physiologically there is 

 no difference. Likewise the symptoms in anaphylaxis are 

 the same whatever the anaphylactogen. 



3. The symptoms induced in fresh animals by the protein 

 poison are identical in every detail with those observed in 

 sensitized animals after reinjection. They come on in the 

 same time, proceed in the same order, and terminate alike. 



4. Friedberger has shown that guinea-pigs killed with 

 the protein poison show the Auer-Lewis phenomenon in 

 the lungs. 



5. Edmunds has shown that dogs killed with the protein 

 poison manifest the same symptoms as those studied in 

 anaphylactic shock. The lowered blood pressure found 

 in anaphylactic shock and in peptone poisoning in dogs is 



