346 PROTEIN POISONS 



high as 1 gram per kilo. Injections of peptone lead to 

 lowered blood pressure and much of the peptone, according 

 to Hofmeister's finding, may be deposited in the tissue 

 where it may be detected at a time when there is none in 

 the blood. He found one-seventh of the peptone injected 

 into the blood in the kidneys, which organs were equiva- 

 lent to only -j-J-g- of the body weight, and concludes that the 

 peptone injected into the circulation has a special predilec- 

 tion for renal tissue. When the amount of peptone injected 

 is large, Hofmeister recovered as much as 84 per cent, of it 

 from the urine. 



Neumeister 1 reviewed the literature of this subject up 

 to that time, and made some additional contributions. 

 He stated that some proteins are absorbed unchanged, 

 that others need only to be dissolved, and that still others 

 must be digested. He stated that the compound proteins, 

 as casein and hemoglobin, when injected into the blood, 

 act like foreign bodies, and are eliminated in the urine, while 

 the simple and denatured proteins, when injected into the 

 blood, do not cause albuminuria. Stockvis did not observe 

 albuminuria after injecting dog, rabbit, or frog serum into 

 dogs or rabbits, but did when he used egg albumen. Leh- 

 mann invariably induced albuminuria by injecting egg 

 albumen intravenously in dogs, but failed to do so when 

 he employed sodium albuminate, or syntonin, prepared 

 from frogs' muscle, myosin, or fibrin. Ponfick found that 

 dogs bear astounding amounts of lamb serum, free from 

 corpuscles, when the injections are made slowly, and under 

 gentle pressure. "The amount of urine was not appreciably 

 increased, although the color became darker, owing to the 

 greater concentration, while not a trace of albumin could 

 be detected." There is no statement concerning the effect 

 upon the elimination of nitrogen; Forster injected large 

 amounts of horse serum into dogs, while the urine remained 

 free from albumin. Neumeister injected into the jugular 

 veins of dogs without inducing albuminuria, the following 



1 Zeitsch. f. Biol., 1891, xxvii, 309 



