352 PROTEIN POISONS 



volume of urine, but without glycosuria, hemoglobinuria, or 

 hematuria. The intravenous, subcutaneous, or intraperito- 

 neal injection in increasing doses, even with long intervals, 

 causes in rabbits a gradual decrease in weight. When the 

 egg-white is injected into the portal vein the albuminuria 

 appears much later than when the injection is made into 

 the general circulation. Subcutaneous injections induce 

 an albuminuria which appears later, is less marked, and 

 persists longer than when the injection is made intravenously. 

 The intramuscular injection of 2 c.c. of egg-white in man 

 was without effect, but when tried upon one who had renal 

 deficiency, albumin appeared in the urine from fourteen 

 to twenty-four hours later. In cases of marked albuminuria 

 injections of egg-white did not materially affect the excre- 

 tion of albumin. In rabbits, dogs, and men the introduction 

 of large amounts of egg-white into the stomach was fol- 

 lowed by albuminuria, though this did not invariably 

 occur in the men. The injection of egg-white into the 

 rectum of rabbits was followed by an albuminuria which 

 appeared later and was more persistent than when it was 

 given by the stomach. Egg-white administered by rectum 

 to man, especially to convalescents from infectious diseases, 

 was followed by an albuminuria, but this did not occur 

 when the albumin was mixed with an active trypsin before 

 injection. In some, not in all, the administration of peptone 

 by rectum was followed by albuminuria as well as peptonuria. 

 Injections of egg-white in rabbits decrease the proteins of 

 the blood, as shown by the refractometer. It appears that 

 not only a part of the foreign protein, but also a part of 

 the blood proteins passes into the muscles. All of the 

 injected protein, probably not the greater part, does not 

 pass through the kidney, at least not within the time of 

 an observation, but much is withdrawn from the blood 

 and held in the tissues. Repeated injections of egg-white 

 lead to marked structural changes in the kidneys. Alimen- 

 tary albuminuria is not due to poisons resulting from the 

 splitting of the protein, but the absorption and elimination 

 of the unbroken protein which is a foreign and poisonous 



