356 PROTEIN POISONS 



December 7, 1909, at 9.30 A.M., 50 c.c. of egg-white was 

 introduced through a tube into the stomach of a rabbit that 

 had been kept without food for two days. Neither at the 

 time nor subsequently did this have any recognizable 

 effect upon the rabbit. 3 c.c. of blood was drawn from the 

 heart of this rabbit at 10.30 and 11.30 A.M., and at 12.30 

 2.30, and 4.30 P.M., and each of these portions of blood was 

 injected intraperitoneally in a fresh guinea-pig. January 

 3, 1910, each of these pigs received intra-abdominally 

 5 c.c. of a dilution of egg-white with an equal volume of 

 physiological salt solution. 



Only one of these pigs developed symptoms of sensitization 

 and this one received blood drawn from the rabbit's heart 

 three hours after the introduction of the egg-white into the 

 stomach. Neither the blood drawn earlier nor that drawn 

 later sensitized guinea-pigs. 



January 8, 1910, at 8 A.M., 50 c.c. of a dilution of egg- 

 white with physiological salt solution (1 to 1) was intro- 

 duced through a tube into the stomach of a rabbit which 

 had not been kept without food. 



Hourly 2.5 c.c. of blood was drawn from the heart of this 

 animal, and injected intra-abdominally into guinea-pigs. 



January 22, 1910, these pigs were treated each with 5 

 c.c. of the egg-white dilution intra-abdominally. The first, 

 second, and third hour pigs showed no sensitization; the 

 fourth and fifth hour ones were sensitized, while the sixth, 

 seventh, and eighth were not. 



That absorption from the stomach of the fed animal 

 should have been more tardy than from the fasting one is 

 easily understood. 



2. Egg-white injected into the rectum of a rabbit may 

 be, in part at least, absorbed unchanged. 



January 8, 1910, at 8 A.M., 50 c.c. of egg-white diluted 

 with physiological salt solution (1 to 1) was introduced 

 through a tube into the rectum of a rabbit. Hourly, 2.5 

 c.c. of blood was drawn from the heart and injected intra- 

 abdominally into guinea-pigs. 



January 22, 1910, these pigs were tested and all from the 



