r , 



THE PARENTERAL INTRODUCTION OF PROTEINS 357 



first to the seventh hour were found to be sensitized to 

 egg-white. 



It appears from this that egg-white may be absorbed 

 from the rectum of a rabbit without being so far altered 

 as to destroy its specific sensitizing properties and that 

 absorption into the blood begins within the first hour and 

 continues for at least seven hours. 



3. Egg-white injected into the peritoneal cavity of a 

 rabbit may be absorbed unchanged. 



December 7, 1907, at 9.30 A.M., a rabbit received intra- 

 peritoneally 50 c.c. of a dilution of egg-white with an equal 

 volume of physiological salt solution. Hourly, 2.5 c.c. 

 of blood was drawn from the heart of this animal and 

 injected intra-abdominally into guinea-pigs. 



January 3, 1910, .these pigs were treated with the egg- 

 white dilution given intraperitoneally. 



All, from the first to the fourth hour, died, the first two 

 in fifteen and the latter in twenty minutes. The fifth hour 

 one was not sensitized. It should be stated that in all these 

 experiments guinea-pigs found not to be sensitized to egg- 

 white were subsequently tested and found to be sensitized 

 to the blood serum of the rabbit. 



4. Egg-white injected intravenously in rabbits quickly 

 disappears from the circulating blood. 



January 3, 1910, a rabbit received intravenously 50 c.c. 

 of a dilution of egg-white with physiological salt solution 

 (1 to 1). Every half hour blood was drawn from the heart 

 of this animal and injected intra-abdominally into guinea- 

 pigs. 



January 12, 1910, these pigs were tested with the egg- 

 white dilution. 



The first two were found to be sensitized to egg-white 

 while the others w r ere not. The pig that received blood 

 drawn at the end of the first hour died in a typical way 

 within thirty minutes, while the blood drawn at the expira- 

 tion of one and one-half hour failed to sensitize. 



December 6, 1909, a rabbit received intravenously 50 

 c.c. of the egg-white dilution (1 to 1). Hourly blood was 



