386 PROTEIN POISONS 



The following is the record of No. 21: 



Time. Dose in c.c. Temperature. 



9.00 A.M. 1 103.0 



10.00 2 101.8 



11.00 3 102.4 



12.00 4 102.8 



1.00 P.M. 5 103.2 



2.00 6 104.0 



3.00 7 103.6 



4.00 8 103.8 



5.00 9 104.0 



After an interval of 140 days this animal was again 

 treated with the following record: 



Time. Dose in c.c. Temperature. 



9.00 A.M. 1 102.0 



10.00 2 103.4 



11.00 3 105.2 



12.00 4 105.8 



1.00 P.M. 5 106.6 



2.00 6 106.4 



3.00 7 105.6 



4.00 8 106.2 



5.00 9 105.6 



6.00 10 106.4 



7.00 106.2 



8.00 105.6 



9.00 106.4 



10.00 103.4 



After the second injection Cheyne-Stokes respiration 

 appeared and continued through the day, but the injections 

 were continued until 6 P.M., and the animal recovered. 



Group V. In this group but one injection was made 

 each day. The dilution contained 26 mg. of protein in 

 each cubic centimeter. The beginning dose was 3 c.c. 

 and each day it was increased by 2 c.c. In No. 6 the dose 

 was given each day at 10 A.M., and was repeated for seven 

 consecutive days. The beginning dose was 3 c.c., two of 

 the larger doses being repeated. In this way a well-marked 

 intermittent fever of mild type was established. After 



