PROTEIN FEVER 403 



It will be seen that in the large majority of the animals 

 the first effect is a slight fall in temperature. We designate 

 this as the primary or short fall. It should be understood 

 that we estimate the falls and rises from the initial tempera- 

 ture. The short fall is followed by the primary rise. In a 

 few instances the primary fall does not occur, or what is 

 more probable, has not been detected. In one animal 

 (No. 136, Table XLII) neither primary fall nor primary rise 

 was detected. The rise is followed by the secondary or 

 long drop. We call attention to some of the great drops; 

 for instance, Nos. 131 and 134, Table XLII; No. 140, Table 

 XLIV; and Nos. 46, 141, and 142, Table XLV. We did not 

 suspect that this treatment would give immunity, and for 

 this reason in our earlier work the recovered animals were 

 not tested, nor have we as yet determined the limits of the 

 immunity secured by these treatments. As is shown by the 

 tables, the immunity is not, qualitatively at least, specific. 

 Animals treated with subtilis or prodigiosus bear, at least 

 from two to three M. L. D.'s of cholera or typhoid bacilli, 

 and the immunity secured by the latter is interchangeable. 



When treated animals are inoculated with living cultures 

 they become sick some hours before the controls, and we 

 are reminded of the immunity induced some years ago 

 in this laboratory with the haptophor, or non-poisonous 

 groups of the colon and typhoid bacilli, and reported by 

 V. C. Vaughan, Jr. (p. 144), by Vaughan and Wheeler 

 (p. 157), and by Vaughan. 1 



The Production of Fever by Repeated Injections of Vegetable 

 Proteins. As was shown in this laboratory some years 

 ago, the vegetable proteins contain the same poisonous 

 group found in bacterial and animal proteins ; conse- 

 quently there seemed no reason why these should not 

 induce fever, and such we have found to be true. We will 

 give here only one illustration. We extracted 10 grams of 

 oat-meal with 100 c.c. of normal salt solution, and with a 

 beginning dose of 0.1 c.c. of the slightly opalescent fluid 



1 Zeitsch-f. Immunitatsforschung, 1909, i, 263. 



