PROTEIN FEVER 409 



6. Protein fever can be continued for weeks by repeated 

 injections, giving a curve which cannot be distinguished 

 from that of typhoid fever. 



7. Protein fever is accompanied by increased nitrogen 

 elimination and gradual wasting. 



8. Protein fever covers practically all cases of clinical 

 fever. 



9. Animals killed by experimentally induced fever may 

 die at the height of the fever, but, as a rule, the temperature 

 rapidly falls before death. 



10. Fever induced by repeated injections of bacterial 

 proteins and ending in recovery is followed by immunity. 



1 1 . The serum of animals in which protein fever has 

 been induced digests the homologous protein in vitro. 



12. Fever results from the parenteral digestion of proteins. 



13. There are two kinds of parenteral proteolytic enzymes, 

 one specific and the other non-specific. 



14. The production of the non-specific ferment is easily 

 and quickly stimulated. 



15. The development of the specific ferment requires a 

 longer time. 



16. Sensitization and lytic immunity are different mani- 

 festations of the same process. 



17. Foreign proteins, living or dead, formed or in solu- 

 tion, when introduced into the blood soon diffuse through 

 the tissues and sensitize the cells. Different proteins have 

 predilection places in which they are deposited and where they 

 are, in large part at least, digested, thus giving rise to the 

 characteristic symptoms and lesions of the different diseases. 



18. The subnormal temperature which may occur in 

 the course of a fever or at its termination is due to the 

 rapid liberation of the protein poison, which in small doses 

 causes an elevation, and in larger doses a depression of 

 temperature. 



19. Fever per se must be regarded as a beneficient phe- 

 nomenon, inasmuch as it results from a process inaugurated 

 by the body cells for the purpose of ridding the body of 

 foreign substances. 



