412 PROTEIN POISONS 



serum, which was found in no instance to be of special 

 value, and in some it greatly intensified the symptoms. 



Our common colds are instances of local sensitization. 

 Schittenhelm and Weichardt tell of a man who was so 

 deeply sensitized by the inhalation of Witte's peptone that 

 he could tell on entering the laboratory whether the peptone 

 flask was open or closed, and some moist peptone painted 

 on the skin caused the area covered to become red. The 

 high degree of susceptibility to odors from the horse shown 

 by some people has already been referred to. It seems in 

 some instances that this susceptibility is transmitted from 

 mother to child. 



A volume might be filled with citations of cases of food 

 and medicine idiosyncrasies. That these are, in large part 

 at least, instances of protein sensitization has been demon- 

 strated by rendering animals susceptible to the same food 

 or medicine by injecting them with the serum of the sus- 

 ceptible individual. In other words, passive anaphylaxis 

 has been established in the animal. In this way Briick has 

 sensitized animals to iodoform and antipyrin with the sera 

 of persons especially susceptible to these agents. 



Thiele and Embleton 1 have made an extensive study 

 of temperature variations. They employed well-fed guinea- 

 pigs. First, they tried non-protein bodies, and with these 

 reached the following conclusions: 



1. Sodium chloride varies in its effects according to 

 its degree of concentration when injected into feeding 

 animals : 



As normal saline it produces only a slight rise. 



As 2 to 2.5 per cent, saline it produces a marked rise. 



As 3 per cent, saline it produces a fall. 



As 5 per cent, saline it produces a rise. 



2. Calcium salts intraperitoneally produce a fall. 



3. Ringer's fluid has no effect on temperature. 



4. Alkalies, very dilute, produce a rise, and stronger, 

 produce a fall. 



1 Zeitsch. f. Immunitiitsforschung, 1913, xvi, 178. 



