PART III. TREATMENT 99 



and some of these were re-admitted to hospital and treated as in 

 Group III. In recording the results of the different methods of 

 treatment it follows that such cases will appear in two tables, for 

 it has happened that where treatment as in Group I has failed to 

 bring about a permanent or even temporary cure, a subsequent 

 treatment by another method has caused the infection to disappear 

 in many cases. 



Group I. Cases treated by Emetin Injections of One Grain a Day 

 for Twelve Days. Table X. 



As already explained, these cases were given an injection of 

 one grain of emetin a day for twelve days. The reason for 

 adopting this line of treatment and the arbitrary limit of twelve 

 days was that one of us (C. M. W.) made a detailed study of a case 

 which was under his care and was treated in this way with a 

 successful result in London last year at the Wellcome Bureau of 

 Scientific Research. The case was one of a carrier of E. histolytica 

 who was passing cysts after having had an attack of dysentery in 

 the Sudan. It was realized that the case afforded a good oppor- 

 tunity of watching the course of such an infection and studying 

 the effect of emetin on the carrier. The case was carefully con- 

 trolled by repeated examination of the faeces and, finally, it was 

 decided to give the patient a course of emetin. The actual 

 injections were kindly given by Dr. G. C. Low in the Laboratory 

 at the Wellcome Bureau of Scientific Research, while the control 

 of the infection was carried on carefully as before. It was noted 

 that the infection disappeared after the second injection of emetin 

 and that there was no recurrence after a long period of control. 

 The findings of the one of us (C. M. W.), who had gone abroad on 

 active service, and who had made the very careful observations on 

 this case, were subsequently published by Dr. G. C. Low (Journ. 

 Trop. Ned. and Hygiene, February 1, 1916). 



As the case just mentioned had responded so successfully to 

 this line of treatment it was decided to try it on a more extended 

 scale, and this was the first method adopted by us in the series of 

 cases recorded here. The cases treated and the results obtained 

 are arranged in Table X in two main groups: (A), carrier cases 

 which were passing cysts of E. histolytica and amoebae without 

 included red blood corpuscles, in stools free from blood and mucus, 

 and (B), acute cases which had actual dysentery and were passing 

 amoebae with included red blood corpuscles. 



