102 HUMAN INTESTINAL PROTOZOA IN THE NEAR EAST 



gave a history of dysentery. Two of the acute cases gave no 

 history of dysentery, the attack in each case being a primary one. 

 The results are shown as follows : 



Carrier cases cured . . . . . . 37 



,, ,, relapsed .. .. ..10 



,, ,, no reaction .. .. ..5 



Acute cases cured . . . . . . . . 



,, ,, relapsed .. .. ..6 



,, ,, no reaction .. .. ..0 



Five of the carrier cases which relapsed, one of those which did 

 not react to the emetin injections (Table X 5 ) and one of the acute 

 cases (Rushworth), were cured later by a combined course of 

 emetin injections and emetin by the mouth (Group III) ; while 

 another two of the carriers who did not react to the emetin injec- 

 tions were cured by a simple course of emetin by the mouth 

 (Spiers and Bennett). 



Group II. Cases treated by a Twelve-day Course of One Grain of 

 Emetin orally administered. Table XI. 



As there had been a certain number of failures in the treatment 

 by emetin injections in Group I it was decided to try a course of 

 emetin by the mouth for twelve days. We were influenced in this 

 direction by the remarkable result obtained in one case (Spiers) 

 who had a long history of dysentery of three years, who had thirteen 

 separate courses of emetin at one time or another and who had 

 proved refractory to a course of emetin injections of one grain a day 

 for twelve days (see Table X). This case with an enormous infec- 

 tion was given emetin by the mouth one grain a day for two 

 days followed by ^ grain a day for seven days. This treatment 

 brought about an immediate and permanent cure (see history of 

 case, Section I). In the series of cases treated in this way emetiii 

 was administered as a tinct. opii mixture as recommended by 

 certain French physicians. The emetin, one grain, is dissolved in 

 tinct. opii fifteen minims, and the fifteen-minim dose given in a 

 cup of tea, preferably at night just before the patient goes to sleep. 

 Having compared this method of administration with that of emetin 

 in keratin-coated tabloids, we have found that it is much more 

 difficult for the patients to retain the tea mixture without vomiting 

 than the keratin-coated tabloids which we used extensively in 

 a later series of cases. The latter, it is true, also often cause 



