134 HUMAN INTESTINAL PROTOZOA IN THE NEAR EAST 



(9) The action of emetin on E. histolytica is not influenced by 

 any coincident protozoal infections. 



(10) In the case of carriers it is doubtful if rest in bed and 

 diet assist the emetin in its action on E. histolytica. Kest in bed, 

 however, is useful in preventing ill-effects of emetin on the patient. 

 Acute cases should be kept in bed on dysentery diet. 



(11) It is doubtful if salines regularly administered influence 

 the emetin treatment in any way. 



(12) Emetin may produce irregular action of the heart when 

 given in large doses. Administered by the mouth emetin readily 

 causes vomiting, which, however, does not hinder the action of the 

 drug on the amoebae. 



(13) All the treated cases which have relapsed have done so in 

 under twenty days after the completion of the course, with the 

 exception of three which relapsed in under thirty days. 



(14) A previous history of a single attack of dysentery (which 

 may or may not have been bacillary but most probably the latter) 

 has very little effect on the treatment of carrier cases. Cases which 

 have suffered from repeated attacks of dysentery are difficult to cure. 

 A history of repeated attacks would indicate an amoabic rather than 

 a bacillary infection. 



(15) Previous emetin treatment does not affect the subsequent 

 treatment unless it; means that there has been a long history of 

 repeated attacks of .dysentery. 



(16) Emetin injected under the skin may be some time in 

 reaching the amoebae, so that its action may be delayed. 



(17) As acute cases of amoebic dysentery so frequently relapse 

 after emetin treatment it is suggested that after the course of 

 emetin (! grains subcutaneously and orally administered) the 

 case might possibly be given a long course of emetin in small doses 

 Jay the mouth as is done in the case of malaria and quinine or 

 trypanosomiasis. 



(18) Emetin by the mouth will frequently get rid of E. coli 

 infections but relapse almost invariably occurs. 



(19) Emetin by the mouth will also temporarily get rid of 

 flagellate infections (lamblia, tetramitus and trichomonas). 

 Bismuth salicylate will also abolish these infections, but- relapse 

 occurs after short courses. Longer courses might give good results. 



(20) Both emetin injections and emetin by the mouth appear 

 to cure I-cyst infections. Emetin by the mouth appears to have 

 some action in abolishing a blastocystis infection. One case of 

 coccidium (isopora) infection appeared to be cured by emetin 

 1 grains a day administered orally and by injection. 



