SCHIZOPHYTA SCHIZOMYCETES 181 



Animals immune. Laboratory animals. 



Pathogenesis. The organism is found present in leprous tissues, almost 

 filling the cells in many instances. Several types of leprosy are differentiated 



'$ " '& *>i|K,^" ; f-^iiP^ 



Fig. 30h. Glanders bacillus. a. Section through "glandereal" 

 tissue, the small rods massed or single. b. Bacilli stained with 

 methyl-blue. After Flugge. 



on the basis of the organ or tissues in the body infected. In many of its 

 aspects, the disease resembles tuberculosis. 



Poisonous properties. The organism has not been successfully cultivated. 

 Poisons are unknown. 



Immunity. 



Bacterium /wf/.?, Lehmann-Neumann 



Disease produced. Bubonic plague. 



Animals infected. Man. 



Animals susceptible. Rat, guinea pig, monkey. 



Pathogenesis. Infection usually cutaneous. The lymph glands become 

 swollen, and hemorrhagic and undergo more or less extensive necrosis, gen- 

 eralized septicemia in many cases, pneumonia and hemorrhages in various 

 mucous membranes, especially in the stomach and endothelial surfaces, such as 

 the pericardium and in various parenchymatous organs, with extreme degenera- 

 tion of the latter. Spleen swollen. 



Poisonous properties. The toxic substance is obscure. The nitrates from 

 young cultures usually show little, or no toxicity ; the older, more. The toxic 

 substance seems to be susceptible to heat and is present in cultures killed by 

 chloroform. 



Immunity. Immunity may be conferred by the injection of sterilized or 

 attenuated cultures, and this vaccination is practiced in some Asiatic countries. 



Microspira comma, Schroeter 



Disease produced. Asiatic cholera. 



Animals infected. Man. 



Animals susceptible. Laboratory animals naturally are immune to the 

 disease, but by preventing peristalsis, and neutralizing the acid gastric juice, 

 some experimenters have succeeded in producing the disease. The guinea pig 

 is susceptible to intraperitoneal inoculation. 



