LHE COAGULATION OF -THE BEOOD 
By GEORGE A. BUCKMASTER, M.A., D.M. (Oxon.) 
Assistant Professor of Physiology, University College, University of London 
PAGE 
1. INTRODUCTORY - : : : ot PE 
2. THE COAGULATION RATE OF “HuMAN BLOOD : - - be hA 
3. STATE OF THE COAGULATION QUESTION AT THE CLOSE OF THE 
YEAR 1880 ‘ . : : : : «585 
4- PHASES OF THE COAGULATION PROCESS : 4 ; pa 
5. THE ROLE OF CALCIUM IN THE PROCESS OF COAGULATION : §e 
6. THROMBIN OR FIBRIN-FERMENT . : SOL 
7. CONSEQUENCES OF THE INTRA-VASCULAR INJECTION OF r PEPTONE 69 
8. CONSEQUENCES OF THE INTRA-VASCULAR INJECTION OF THROMBO- 
KINASE : ; key 2 
g. SUBSTANCES WHICH DIRECTLY HINDER COAGULATION BOTH IN- 
SIDE AND OUTSIDE THE BODY : é ae 
10. THE HISTOLOGICAL APPEARANCES DISPLAYED WHEN BLOOD 
COAGULATES . : : ‘ : : 3 P : ere 
1. INTRODUCTORY 
In all vertebrate and invertebrate animals which possess either 
a true vascular or a pseudo-hzmal system, it is known that the 
liquid within these channels is in a state of continual or 
intermittent movement during life. In order that this condition 
shall be maintained, the blood or lymph or tissue-fluids con- 
tained within both the lymphatic and blood-vascular system 
must possess only a small degree of viscidity, which, apart from 
the suspended morphological bodies, depends upon their 
content in protein substances. The actual viscidity of blood 
varies scarcely at all during life, though its viscosity appears 
to vary within limits and to be largely dependent upon the 
corpuscular richness ; an excessive number of corpuscles in the 
unit volume increases the friction-coefficient of the blood, thereby 
throwing extra work upon the heart. Blood which escapes 
from the blood-vessels into the extra-vascular regions of the 
body may or may not exhibit that change in viscidity which all 
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