86 



The Endocrine Organs 



no effect (tachyphylaxis l ) ; or, if any, not a rise but a fall of blood-pressure 

 which may or may not be followed by a slight rise (fig. 57). Frequently 



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a preliminary fall precedes the rise produced by the first dose. Probably, 

 therefore, there is present in the extract a second autacoid which is 

 antagonistic to the first and should be classed with the chalones or in- 

 hibitory autacoids. The substance which causes the fall of blood-pressure 

 is not choline, although the curve obtained resembles that caused by 

 1 raxvs, quick, and <pv\a£is, protection. 



