

146 



The Endocrine Organs 



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in the male this re- 

 sult was not obtained. 

 That corpora lutea are 

 related to the develop- 

 ment of the mammary 

 gland during preg- 

 nancy appears from the 

 experiments of Ancel 

 and Bouin and of 

 O'Donoghue, who have 

 found that if in the 

 virgin rabbit a Graafian 

 follicle be ruptured 

 (even by mechanical 

 means) so that a corpus 

 luteum develops, the 

 mammae undergo evo- 

 lution ; whereas if a 

 corpus luteum fails to 

 form there is no such 

 evolution. Hammond 

 and Marshall state that 

 under these circum- 

 stances the develop- 

 ment of the mammae 

 may even proceed so far 

 as to produce free se- 

 cretion of milk. Ott 

 and Scott have obtained 

 marked development of 

 the mammae, and even 

 secretion of milk, in 

 young virgin rabbits 

 injected subcutane- 

 ously at frequent in- 

 tervals for a month 

 with extract of corpus 

 luteum. 



It is further stated 

 by Ancel and Bouin 

 that if all the corpora 

 lutea are destroyed in 

 a pregnant rabbit the 

 development of the 

 mammary gland is 



