al 24 THE INTERNAL SECRETIONS—19290 
cult and painful menstruation, with the accompanying 
back and headache; hysteria; melancholia; neuras- 
thenia are symptoms with which we all are familiar. 
From time immemorial we physicians have been 
treating those patients by giving sedative, tonic, and 
digestive drugs, also operations, electricity, baths, mas- 
sage and suggestion with little or no success at all. 
Now, it is in the treatment of just such cases that I 
have had the most successful results with the glandular 
extracts. I dare say you could hardly find a physician 
who is not familiar with the action of adrenalin or who 
has not witnessed the immediate and powerful specific 
effect of pituitrin on the uterus at the obstetric. bed. 
Yet, there are some doctors who doubt the efficacy of 
the other organic extracts. They also doubt the effi- 
cacy of those two in so far as being remedial in the 
treatment of disease. However, the number of the 
doubters is rapidly declining. Those who remain are 
of two classes: Those who have never had any experi- 
ence with organotherapy, who have not given the mat- 
ter any deep thought; and those who have used only 
the monoglandular extracts, losing sight of the fact 
that the endocrine glands are so closely interrelated 
that a monoglandular dysfunction is, perhaps, a physio- 
logical impossibility. 
I report in detail the following case as being typical 
of endocrine dysfunction, and evidence of the results 
of pluriglandular treatment. No doubt the condition 
of this poor woman can be paralleled many times by 
any physician of a few years’ experience, especially 
those giving attention to chronic ills: 
Mrs. R. F. W., age 36, mother of three children, 
youngest three years. No abortions. Family history 
good. Personal history good until beginning of present 
illness. 
Present illness began in November, 1918, closely fol- 
lowing influenza. In so far as the special symptoms of 
influenza were concerned she soon recovered, but soon 
noticed that her digestion was not normal. She would 
