50 THE INTERNAL SECRETIONS—1920 
prescribing a single organotherapeutic product, where- 
as, due to the deficiency of one, all are below par, as 
they have lost the stimulus which they get from one 
another and which also stimulates themselves, no mat- 
ter which gland was at fault in the beginning. In fact, 
as to whether a single gland was at fault even in the 
beginning, is not above question (11). Time and fur- 
ther clinical experiment will show these relationships 
more definitely, 7. e., that there may be a possibility of 
measuring the exact amount of stimulus one gland has 
on all of the others. 
At the present time we know that certain deficiencies 
affect the well-being of many individuals, and that 
overproduction does likewise. Brown-Séquard noted 
the difference on himself by the ingestion of gonad 
_ secretions, and being a pioneer, did not perceive at the 
time that he not only replaced gonad substances, but 
stimulated the production of new endocrine substances 
by autohormonic influence. [Hallion calls this “homo- 
stimulation.”—H.R.H.] His feeling of well-being and 
ability to perform tasks which before were considered 
impossible, was due to more than the increased gonad 
function. His experiments show that the influence of 
the secretion of the Leydig cells on some of the other 
endocrines is very great. Had the stimulus been given 
to the sex glands only there could have been only an 
increase in sexual power, whereas, he mentions more 
the power to stand physical strain and sustained men- 
tal exertion; for sustained mental exertion itself has 
an effect both on physical power and the testes. 
Before maturity the influence of the gonads is small 
or absent, but once it is developed it must impart cer- 
tain stimuli to other endocrine organs which they 
afterwards need to maintain the balance. If this were 
not so, the so-called pituitary eunuch, or other men who 
have become impotent, would not waste lavish sums to 
regain this libido, while the true eunuch, who was cas- 
