INTERRELATIONS OF SECRETIONS 5] 
trated before puberty, is not exercised about his condi- 
tion. In the former is a despondency and lack of force 
caused by the crying need for these stimuli, while 
eunuchs often have buoyant dispositions and are raised 
to places of power and trust (12). The same parallel 
is seen in most women following or during the meno- 
pause, where nature, or the internal secretions, are 
below par until adjustment is made between the endo- 
crine organs without the ovarian stimulus. 
Just as it is difficult for the internist to think of a 
pure type of infection, so it is hard for the endocrinolo- 
gist to think of a single type of endocrine disturbance. 
The makers of vaccines and the developers of new 
ideas along this line take this fact into consideration, 
while an autogenous vaccine contains a definite propor- 
tion of various organism, according to the bacterial 
count. It is very seldom that a single organism can be 
blamed for all of the symptoms. Much less then can 
the endocrinologist think of a disturbance of a single 
gland because one is a dominant factor. 
Having established the relationship of various 
glands, the application of this knowledge to clinical 
cases becomes of importance. The first principle to be 
adhered to is that of balance. To determine a balance 
of internal secretions each case must be approached 
according to the symptom complex, bearing in mind 
that many organs may be involved in the process. For 
instance, in cretinism: we have here a hypofunction 
of certain glands and need to make up the deficiency. 
We give them certain substances secreted by the thy- 
roid, pituitary body and adrenals. As this is the purest 
approach to a single endocrine disturbance and thyroid 
function is not often present at all, thyroid substance 
will have to be given in greater proportion than the 
other glands. Better than the secretions themselves 
is to give standardized macerated glands which. no 
