THYROID IN INFECTIOUS DISEASES 89 
animal was ill, it did not eat for two days, it sat quietly 
in a corner of its cage, whilst on the other hand, the 
second animal did not show any symptom at all. — 
Then I did some clinical work on patients. In all 
cases where typhoid infection was a possibility I exam- 
ined the blood for bacilli. Nearly always this was nega- 
tive, and the patient did not get typhoid fever. In 
three cases it was positive and in these cases imme- 
diately thyroid was given by mouth. I will very briefly 
report these cases here: 
1. <A boy of 17. Complains of headache, thirst and 
dullness during some days; spleen not palpable; no 
bronchitis; no temperature between 38.4° and 40.2°; 
pulse, 74, dicrotic; the blood culture showed typhoid 
bacilli. Agglutination on the fifth day of the disease, 
1:25. Then 40 milligram thyroid was given 3 times 
daily. On the sixth day the agglutination is 1:200; on 
the seventh, 1:250; on the 8th, 1:2000. After that it 
did not rise any more. 
2. Man of 22. Same complaints as No. 1. Spleen 
not palpable; there is bronchitis; no rose spots; tem- 
perature goes to 40°; pulse, 90, dicrotic; typhoid bacilli 
were found in the blood. Agglutination on the fourth 
day of the disease, 1:10 thyroid was given 3 times 
daily. Forty milligram agglutination on the fifth day, 
1:200% sixth day; 1:1500; 8th day, 1:2500: This last 
was the maximum figure. 
3. Man of 24, with tuberculosis of the lungs and 
tubercle bacilli in sputum; was under observation dur- 
ing some time when one day temperature rose to 39.4°. 
Some days, before the patient had been dull, the blood 
contained typhoid bacilli. There was no agglutination. 
Thyroid was given from the third day; fourth day, titer 
1:100; fifth day, 1:300. Sixth day the patient had a 
collapse and died suddenly. We see here in three cases 
how by the influence of thyroid therapy the formation 
of antibodies begins much earlier than in other cases. 
