90 THE INTERNAL SECRETIONS—1920 
For this to be accomplished, it is necessary that a diag- 
nosis be made as soon as possible. 
In five cases of typhoid fever, where no bacilli were 
found in the blood and where the Widal-reaction was 
already positive when I began with thyroid tablets, 
I have not seen the slightest influence on the measure 
of agglutination. In the same way I did not observe a 
difference in agglutination after vaccination against 
typhoid fever in persons taking or not taking thyroid 
tablets. It is difficult, even often impossible, to diag- 
nose typhoid in the beginning of the disease. If, how- 
ever, the diagnosis is made early, we ought to think of 
the possibility of increasing the resistance of the pa- 
tient by giving him thyroid. Perhaps other endocrine 
products may have the same or an even better effect, 
but one thing is certain: Too often the endocrine sys- 
tem is forgotten in the study and the treatment of acute 
infectious diseases. 
BIBLIOGRAPHY 
1. Charrin (A.): Les interventions chirurgicales en face 
des nouvelles donnes de la physiologie et de la 
pathologie generale, Semaine med. (Paris), 1905, 
xxv, 61. 
2. Sajous (C. E. de M.): “Internal Secretions and Prin- 
ciples of Medicine,” F. A. Davis Co. (Philadelphia) , 
1916, VII Ed., pp. 143, 623. 
3. Lorand (A.): Insuffisance thyroidienne comme facteur 
etiologique dans la pathogenie de la tuberculose, 
Congrés de la Tuberculose (Paris), 1905. 
4. Miller (L.): De l’influence de l’opotherapie thyroid- 
ienne et du traitement iodé sur le pouvoir hémo- 
lytique du sérum, Centralbl. f. Bakteriol. (Jena), 
1909, 1, 462. 
Miller (L.): Recherches sur le lieu et le mode d’or- 
igine des cytolysines naturelles (alexines et ambo- 
cepteurs normaux) et les moyens d’en provoquer 
Vhypersécretion, Centralbl. f. Bakteriol. .1. Abt. 
(Jena), 1910-1911, lvii, 577. 
6. Marbe (S.): Les opsonines dans les états thyroidiens. 
(a) Les opsonines des animaux hyperthyroidés, C. r. 
Soc. Biol. (Paris), 1908, lxiv, 1058. (b) Les op- 
sonines des animaux éthyroidés, ibid., 1113.. (c) 
Les opsonines et la phagocytose chex les myxoedé- 
mateux, ibid., 1908, Ixv, 612. 
7. Id.: (d) Action directe in vitro du corps thyroide, 
ibid., 1909, Ixvi, 482. (e) La phagocytose chez les 
on 
