102 THE INTERNAL SECRETIONS—1920 
negative for evidences of nephritis. Blood sugar 125 
mgm. per 100 c.c. 
Allen treatment for glycosuria cleared up the urine; 
the blood sugar values remained practically unchanged, 
ranging about 115 mgm. This treatment gave no relief 
of either symptom. Organotherapy relieved all symp- 
toms in approximately fifteen days and, while on organ- 
otherapy and a diet especially rich in carbohydrates, he 
showed no glycosuria. 
Case IV. Female, single, aged 34 years. Chief com- 
plaint: Weakness, violent headaches in the morning, 
chiefly occipital; dizziness; edema of the hands and a 
continuous fever for a period of eighteen months, rang- 
ing from 99.2 to 100.6 degrees per os. The patient is a 
trained nurse, and she has gained weight in spite of 
symptoms. 
Physical examination: Negative, except for a pulse 
of 100 to 105 without a cardiac lesion. Overweight, 25 
Ibs. There is no ascertainable cause for the tempera- 
ture, complete radiographic examination of all possible 
foci in head, chest, and abdomen being negative. 
Blood pressure, 145 mm. systolic. 
Laboratory examination: Urine, 1450 ec.c. in 24 
hours; sp.gr., from 1010 to 1015; faint trace of albu- 
men and an occasional cast. No evidence of nephritis 
upon special examinations. 
THE TWO SYNDROMES 
There are then two distinct pictures, one referable to 
the ovary and similar or identical with the condition 
commonly recognized as hypo-ovarism, which lasts for 
from two to five years; and the other referable to the 
thyroid. The latter presents the symptoms usually 
associated with a chronic nephritis and lasts for from 
two to eight years. The ovarian type occurs only in the 
sexually active female, the thyroid type may occur in 
the sexually active female, but is more likely to develop 
