THE THYROID-OVARIAN SYNDROME 103 
after the menopause and is the type seen in the male. 
With the progress of the condition, irrespective as to 
which gland is first involved, the terminal condition 
presents a predominance of the thyroid symptoms. As 
illustrative of the terminal condition, two cases, one 
male the other female, are cited. 
Case I. Female, married, age 38 years. One child 
died of intestinal obstruction, three others are alive 
and well. During the last pregnancy, four years 
previous, she complained of headache, vertigo and a 
slight and transient edema of the legs. At that time 
her blood pressure, which one year previous had been 
normal, was found to be 180 mm. systolic and a trace 
of albumen and casts were found in the urine. The 
diagnosis of impending eclampsia was made and she 
was placed in the hospital under close observation. The 
complaint of headache became so intense at the mid- 
dle of the eighth month that a premature labor was 
induced. After delivery the headaches became less 
severe, the vertigo intermittent and more severe, pe- 
riods of double vision occurred, and the blood pressure 
and urinary findings remained as before delivery. A 
diagnosis of chronic nephritis was made. 
The conditions remained as just described for a pe- 
riod of two years when an intolerable itching developed 
which kept the patient awake at night. The skin be- 
came boggy to such a degree that larger shoes had to 
be worn, and rings had to be removed from the fingers. 
There was an increase of 49 lbs. in weight. Attacks 
of double vision became increasingly more frequent and 
lasted longer. A backache developed about six months 
ago. 
After the birth of the last child there was a period 
of six months during which menstruation, while regu- 
lar, was very profuse, but latterly it had become irreg- 
ular—being sometimes four to six weeks overdue—and 
when on time, it was scanty, being approximately one- 
