THE THYROID-OVARIAN SYNDROME 105 
lost an additional ten pounds. It might be noted that 
while she had been on a restricted diet for several 
years, during organotherapy she was placed on a full 
diet. Thyroid alone in one-half-grain doses was given 
for the next two months, with the result that she did 
not menstruate the second month and again ten days 
before her period had double vision for five days. The 
medication was reinstated as before, for one month, 
the double vision cleared up and did not return at the 
next menstrual epoch. Between two menstrual epochs 
she was given pituitary gland substance, and after four 
days of medication, double vision recurred worse than 
ever before. It subsided promptly when pituitary sub- 
stance was discontinued. At the present time her 
status is that of a well woman—blood pressure 125 sys- 
tolic, symptom-free, urine normal, menses normal, total 
loss of weight 55 lbs. 
Case II. Male, age 56 years, married, four children, 
all alive and well; negative family history except that 
he is the brother of Case IV, thyroid group. About 
seven years ago the patient noted a gradual increase in 
weight and the onset of attacks of vertigo and short- 
ness of breath, this last being attributed to his gain in 
weight. Five years ago, though previously free from 
headaches, he commenced to have violent morning 
headaches, which aroused him from sleep at about 5 
A. M. These headaches were frontal and temporal, 
and wore off during the day. He had occasional itch- 
ing of the skin at times violent enough to prevent him 
from sleeping. He had a nocturnal polyuria. Latterly, 
he had frequent periods during which he could not read 
the paper because of double vision. Six months before 
the present period he had been rejected for life insur- 
ance because of high blood pressure. Within the past 
year he noted a sudden dimunition in sexual power. 
Physical examination: Overweight, 30 lbs.; blood 
pressure, 250 mm. systolic; face “puggy” and cyanosed; 
