152 THE INTERNAL SECRETIONS—1920 
favors a change in this mechanical obstruction to the 
circulation in these so-called “precapillary areas.” 
Many remarkable clinical experiences with both thy- 
roid therapy and various pluriglandular formulas in 
the control of functional high blood pressure’ has em- 
phasized in my own mind a very important series of 
therapeutic possibilities in the treatment of this condi- 
tion. It is first necessary to establish the fact that 
hypothyroidism is present and prominent as, for exam- 
ple, with my thyroid function test,’ and then we have 
a most rational and scientific means of treating this 
particular condition; and if, in conjunction with other 
benefits there is a change for the better in the high 
blood pressure, then we are pleased. It may be said in 
this instance that another useful means of modifying 
functional high blood pressure due to toxemic irritation 
of the adrenals is the use of the antagonistic function 
of the pancreas which is known to balance adrenal 
medullary activity. We have had a good deal of experi- 
ence in the use of combinations of thyroid with pan- 
creas substance (not pancreatin) and many times the 
sphygmomanometer shows encouraging changes in the 
systolic pressure. 
