158 THE INTERNAL SECRETIONS—1920 
shown that emotions such as fear, anger, grief—in fact, 
any strong emotional excitement—will stimulate the 
adrenals, and further, that if the stimulus is continued 
over a period of time, the stimulation gives way and 
depression follows. This, in fact, applies to all stimu- 
lants. 
The observations of Kaplan (13) on changes in the 
formation and position of the teeth in relation to the 
internal secretory apparatus are indeed interesting and 
exceedingly helpful in deciding whether a given case is 
really congenital or only an acquired hypofunction. 
This, I believe, is vitally necessary in order that we may 
have some mental concept of the results we expect to 
attain by organotherapeutic measures. My own ob- 
servations agree with Kaplan (13), i. e., that blunt, flat 
upper cuspids, the so-called eyeteeth, are an indication 
of slow-acting adrenals. 
We can get the internal secretory mechanism of the 
inherited case to working more normally by gland feed- 
ing, but the slightest little mishap will throw the whole 
thing out of balance again, whereas, in the acquired 
case, our treatment is more prompt and decisive in ac- 
tion, and the results of much longer duration. To lend 
emphasis let us contrast the following cases: 
Mrs. H. J. G., age 27, left Wisconsin in 1908 because 
of asthma, came to Southern California and asthma 
disappeared immediately on arrival in Los Angeles. 
She remained free for three years, when in 1911 an at- 
tack of appendicitis occurred. This was followed by a 
recurrence of the asthma, which continued to Decem- 
ber, 1916, when I first saw her. Upon examination, I 
decided she was suffering from hypocrinism or hypo- 
function of the pituitary, thyroid, adrenal and ovarian 
glands. Incidentally, it is interesting to note that her 
mother, at this time, also showed evidence of pituitary, 
thyroid and adrenal hypofunction. A combination of 
pituitary, thyroid, adrenal and ovarian glands was 
