TZ, THE INTERNAL SECRETIONS—1920 
adrenalin hyperglycemia is accompanied, as shown by 
Achard and Desbouis, by a deficient glycolysis, that is, 
a lessening of the capacity of the tissues to burn and 
fix the glucose of the blood. 
With the assistance of Ch. Achard and A. Ribot, we 
have taken up the question of the action of adrenalin 
upon the consumption of glucose, and for that purpose 
we have studied, in the dog, the characters of the 
hyperglycemia provoked by an injection of glucose and, 
these characters being known, the variations of this 
hyperglycemia when a certain quantity of adrenalin is 
injected with the sugar. In every experiment, glucose 
was injected in aqueous solution (35 grams to the litre) 
and at the beginning of the experiments was with- 
drawn before the injection and then every ten minutes 
following the injection. Our method has been done 
following the procedure of A. Epstein, which allows 
volume of blood in a great proportion and, therefore, 
without altering the quantity of sugar in the blood. 
The duration of the hyperglycemia, provoked by the 
injection of glucose, seemed to us a most important 
point, indicating the capacity of the organism to fix this 
sugar. Ina series of healthy dogs we obtained the fol- 
lowing results: 
1. A dog, weighing 12 Kg., was injected with 12 
grams of glucose; after 2 minutes the quantity of sugar 
in the blood went from 1 gm. per litre, to 3.10 gm.; the 
glycemia came back to the starting point after 40 min- 
utes. 
2. <A dog, weighing 19 Kg., was injected with 12 
gm. of glucose; after 2 minutes the sugar went from 
0.9 gm., to 2.65 gm. and came down to 0.90 gm., 30 
minutes later. 
3. A dog, weighing 19 Kg., was injected with 10 
gm. glucose: the quantity of sugar went from 1.05 gm., 
to 2.85 gm., after 2 minutes and came back to the start- 
ing point in 20 minutes. 
