174 THE INTERNAL SECRETIONS—1920 
then the effect of adrenalin, and lastly, the effect of 
both together. 
A dog, weighing 15 Kg., was injected with 3.5 gm. of 
glucose, 2 days after, with 1 mgm. of adrenalin, and 
lastly, 2 days later, with 3.5 gm. of glucose, plus 1 mgm. 
of adrenalin. 
Quantity of sugar in blood after an injection of: 
3, 5 gm. glucose 
3,5 gm. 1mg. + 1 mg. of 
glucose. adrenalin. adrenalin. 
Before 22 ike 0, 95 0, 95 0,95 
2 Min: afters). 36% vss. 1, 40 —— LO 
LOsmin afters uno: 110 1, 40 2-10 
20) Win. SREter ya's hela ibe 1520 1,70 
AQMMIne aLrterin.s oss OF ite 0, 92 1,30 
ihr, 20-min. after: >: -.. ane 1,10 
Sihrs’ atterw. 5.05 22s) see 0,95 
This shows that the addition of adrenalin to glucose 
brings an increase of sugar greater than the sum of 
the increases brought by adrenalin alone and glucose 
alone. In addition, this hyperglycemia lasts longer 
since it lasts after an hour and twenty minutes. It is 
as if the organism, under the influence of adrenalin, 
could no longer fix and burn up the sugar: its power of 
glycolysis seems absent. 
These experiments seem to us to develop some prac- 
tical applications; in therapeutics it seems to us that 
there is an incompatibility between glucose and adre- 
nalin: the serum containing both glucose and adrenalin 
seems not to be used. 
But how are the conditions of hyperglycemia and in- 
compentency of glycolysis produced? Numerous opin- 
ions have been expressed about this. With Ch. Achard 
and A. Ribot, we have tried to solve this preblem by 
studying the effect of an injection of adrenalin after the 
extirpation of the pancreas. This is a problem so much 
the more interesting as the relations between the adre- 
nal glands and the pancreas have been recently sought 
