BIOLOGICAL EFFECTS OF ADRENALIN 175 
for (R. Pemberton & J. E. Sweet—E. Gley—Graham, 
Lusk & Riche—F. C. Mann & Della Drips). 
1. Dog weighing 10 Kg. Injection of 1 mg. of 
adrenalin. Sugar in blood 
after pancreas 
Normal Dog. was out 
LEIS 7 a/c Reg) Oe ay ie eee pi eeer er 4 ie 0, 65 3, 20 
MOMMIES, BTLELE ese wetere cee ea ce «© 0, 80 3 
PAD CT Viagra eh See Seer Oa iar are ee a 0, 60 3, 20 
2. Dog weighing 10 Kg., having its pancreas re- 
moved 6 days previously. Injection of 2 mg. of adre- 
nalin into the saphenous vein; the quantity of sugar, 
within the following half hour, remains at 3 gm. per 
litre. Sugar in blood. 
IBYENIOS 2, councis Recesene D Cid ce I eRe ESO ame eI aE 3 gm. 
Atterezeme. (Gf AGFENAIMN wi. cjas 2 a aye edie = s.etelacscesmese 3 gm. 
MOMENI LeS sal bei care, castveccols ts cis aheiebeteyayele ore Seeue, oscke 3 gm. 
Pe MMTISUAUI GOS LE GET grote aS te ccs 526 7altae Hdl aielole\ai ccelaieis's 3 gm. 
PUMMCTTUMNTUEGOS), VE GOR ale su. 6 ace tyne S15 scaeneee lea. eiie.8 Buses 3 gm. 
Such conditions do not exist if the extirpation of the 
pancreas is not complete, and a dog, which had had the 
pancreas removed 13 days before, but still had a stump 
of pancreas left, as was shown by the autopsy, showed 
an adrenalin hyperglycemia: 
Dog weighing 9 Kg., had its pancreas out on May 21, 
was injected June 4, with 2 mg. of adrenalin. 
Sugar in blood. 
iL 
BYE Capa) © Sie a ee ST. RO Re er ee 
a WSS cet a yb [Seer 0 ot eek SE ae DAE 1,30 
SUPMIMNGLESaAnber piss tS Sates aia s fsis ow creletarsho mse ahs ats 1,50 
The animal was killed and a stump of pancreas about 
the size of a pigeon’s egg was found against the duode- 
num. These experiments show that adrenalin hyper- 
glycemia is not produced after the extirpation of the 
pancreas. Finally, it is as if adrenalin injected into a 
dog prevented the action of the glycolytic ferment from 
the pancreas, its action on glucose seems indirect and is 
suppressed by the previous suppression of that ferment 
by the extirpation of the pancreas. 
