176 THE INTERNAL SECRETIONS—1920 
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THE ACTION OF ADRENALIN ON THE HEART AND VEINS 
The temporary hypertension produced by an injec- 
tion of adrenalin is a very well-known phenomenon. 
It seemed to us of interest to consider the disorder 
brought by large doses of adrenalin, which would pro- 
duce an exaggerated hypertension and might even cause 
the death of an animal. 
That edema of the lungs is caused by an injection of 
adrenalin is fairly well known; but in addition to this 
reaction in the pulmonary circulation, we have observed 
a more frequent manifestation in the pericardium. 
First Experiment—A dog weighing 7 Kg., was in- 
jected with 5 mg. of adrenalin, then, 30 minutes after, 
with 3 mg. and 1 hour later with 1 mg. of the same 
substance. The animal was killed an hour and a half 
after the beginning of the experiment. Autopsy 
showed no pleuropulmonary injury, but the heart 
showed in the myocardium some signs of hemorrhage 
in the left part only (right part normal). Those 
hemorrhages of the myocardium were accompanied by 
a slight, rosy discharge, containing 56 g. of albumin 
per litre and some heminfiltration of the pericardium. 
Second Experiment—A dog, weighing 7 Kg., was in- 
jected with 7 mg. of adrenalin within an hour; the ani- 
mal was killed and hemorrhages in the myocardium 
were found in the right as well as in the left part of the 
heart with a discharge of the pericardium of 6 mils. 
Lungs as usual. 
Third Experiment—A dog, weighing 12 Kg., was in- 
jected at 4:45 with 5 mg. of adrenalin, and at 5 with 
6 mg. At 6 o’clock the animal was killed by puncture 
of the bulb and 13 mils. of a slightly pink liquid were 
found in the pericardium. The myocardium showed 
