178 THE INTERNAL SECRETIONS—1920 
III 
THE ACTION OF ADRENALIN ON SHIVER 
Adrenalin has an action on certain nervous manifes- 
tations, particularly upon shiver. The experiments of 
Professor Ch. Richet have shown that a chlorilized dog, 
having a temperature of 34° C., was taken at first with 
a shiver on inspiration, then when both inspiring and 
expiring a violent shivering occurred so as to increase 
inspiration and expiration evidently in order to raise 
the temperature. 
Our experiments have shown that if an animal in 
such a plight was injected with 1 mg. of adrenalin, its 
shivering was stopped instantly, as well as the respira- 
tion. If only 1% mg. were injected, the respiration 
might not be altered, but the shivering would be 
stopped. It seems that the center, which controls shiv- 
ering, is more sensitive to adrenalin than the center 
which controls respiration. 
Adrenalin momentarily stops the thermic shiver; it 
also stops the reflex shiver observed on an animal that 
is awake. Lastly, it prevents the development of the 
shivering caused by the injection into the veins of cer- 
tain substances as sugars. 
If some glucose serum is injected into a non-anesthe- 
tized dog, immediately a violent and long continued fit 
of shivering is produced; if, on the contrary, serum 
containing both glucose and adrenalin is injected, the 
shiver is not produced. Thus adrenalin seems to us an 
excellent remedy for the shivering, whatever may be its 
cause. 
IV 
THE ACTION OF ADRENALIN IN ANESTHESIA 
Experimentalists do not fail to be struck with the 
dejected look of the animal which, when awake, is in- 
