BIOLOGICAL EFFECTS OF ADRENALIN 179 
jected with adrenalin. The dog which, but a moment 
ago, was barking and lively, becomes quiet and silent. 
That fact must be remembered, and J. Gautrelet praises 
the use of adrenalin in anesthesia of animals by means 
of chloralose. His experiments show that the period 
of the excitement before anesthesia, caused by chlora- 
lose, is suppressed if adrenalin is injected previously. 
In man, Pierre Delbet, Herrenschmidt, Beauvy and 
Carlo-Oliva have considered the action of chloroform 
on the adrenal glands. 
It seemed worthy of interest to us to study the effect 
of adrenalin upon the resistance of guinea pigs to 
chloroform. Under a glass bell, containing about 30 
litres, two guinea pigs were set. They weighed the 
same; the one was a control; the other was injected 
under the skin with 2/10 mg. of adrenalin; chloroform 
vapor could be blown through the receiver. Anesthesia 
lasted from 10 to 25 minutes, then the animals were re- 
moved. The animals were under observation imme- 
diately after and on the following days; but often this 
anesthesia was enough to cause the death of one of the 
animals. 
The results of our experiments show: 
First, in 10 controls: 
One animal recovered. 
Nine animals died, of which 8 were under the bell 
during anesthesia, and 1 dying after the animal had 
been removed and was no longer under chloroform. 
Second—In 10 guinea pigs having been injected with 
2/10 mg. of adrenalin: 
Two animals died (one immediately, the other some 
days after). 
Eight animals recovered. 
Such figures should suffice to prove the value of adre- 
nalin as a preventive of the shock caused by chloro- 
form. 
