196 THE INTERNAL SECRETIONS—1920 
thyroid glands also influence carbohydrate metabolism 
through a secondary influence on the adrenals and pan- 
creas. The pituitary, thyroid, adrenals and gonads in- 
fluence the metabolism of fat. 
It is known that direct lesions occur in the endocrine 
organs and frequently certain clinical syndromes are 
connected with such lesions of one organ or another. 
Experience has shown that the endocrine organs are 
closely connected with each other functionally, so that 
a disturbance in one involves, according to the circum- 
stances, a more or less profound disturbance in the 
function of a smaller or larger number of the others. 
From this we can infer that pluriglandular disorders 
are much more frequent than disorders involving a 
single gland of internal secretion and, therefore, the 
administration of one or more synergists or pluriglan- 
dular therapy, may radically alter the results in a given 
case for the better and determine the final outcome. 
I regard endocrinology and organotherapy as of the 
utmost importance in both the diagnosis and the treat- 
ment of many of the problems of pediatrics. 
BIBLIOGRAPHY 
Barker (L. F.): Some of the commoner types of dis- 
eases of the endocrine glands, J. Med. Soc. N. Jersey 
(Orange), 1914, xi, 493. 
Bartlett (F. K.): A case of acromegaly and poly- 
glandular syndrome, with special reference to the 
pineal gland, Arch. Int. Med. (Chicago), 1913, xii, 
201. 
Bainbridge (W. S.): The internal secretions; some 
clinical aspects illustrated, Maine Med. J. (Port- 
land), Aug. 1915. 
Biedl (A.): “Innere Sekretion, Ihre physiologischen 
grundlagen und ihre bedentung fur die pathologie, 
Urban & Schwarzenberg (Berlin & Wien), 1910; 
Ibid., “The Internal Secretory Organs: Their Phy- 
siology and Pathology,” transl. by Linda Forster, 
John Bale, Sons & Danielsson (London), 1912. 
Bandler (S. W.): Internal secretion in obstetrics and 
gynecology, Amer. J. Surg. (New York), 1917, 
Xxx, 156; 
