THOUGHTS ON INTERNAL SECRETION 203 
To the sexual glands belong that rare and evanescent 
phase of life known as youth, characterized by an ex- 
uberance of spirit, and energy run riot, and physically, 
by the bloom on the cheek, the light in the eye, and that 
illumination of countenance, which has given rise to 
the saying that, “Even the devil was handsome when 
young.” 
Zoth and Pregl, by a series of carefully conducted ex- 
periments, have shown that greater vigor and an in- 
creased muscular capacity follows the oral administra- 
tion of testicular extract. 
The next organ to receive the attention of the physi- 
ologist, was the adrenal gland. It was noticed that dur- 
ing fetal life the adrenals were much larger than the 
kidneys; that at birth they are about equal in size, and 
that a process of involution is immediately inaugurated, 
which slowly brings about old age. 
It was further learned that the organ is composed of 
two separate glands, which in the lower animals re- 
main apart; that the upper or cortical portion had the 
greatest effect of all glands on general body develop- 
ment, the evolution of the organs, and the growth of 
hair. A tumor of this part of the gland will cause a 
child of 5 to appear 10, or even 15 years of age. In 
men of the Esau type, who have much hair over chest 
and abdomen, and women who have mustaches, there is 
an unusual activity of the cortical portion of their adre- 
nals. Hemorrhage of the adrenals is far more fre- 
quent than is supposed, and is perhaps less frequently 
recognized than any other acute trouble in the body. 
Many a case of sudden pain in the abdomen, operated 
for appendicitis or perforation of the abdominal vis- 
cera, and nothing found, is a case of hemorrhage of the 
adrenals. 
The one symptom of insufficiency of the medullary 
portion of the adrenals, is weakness and languor, with 
low blood pressure. Neurasthenia, accompanied by a 
