206 THE INTERNAL SECRETIONS—1920 
all animals, and should be used wherever iodine is indi- 
cated. In long-standing cases of exophthalmic goitre, 
which have passed over into the myxedematus state, 
thyroid extract is the treatment par excellence. In 
keratitis, and iritis, with cloudy cornea and fluid, I have 
known it to work in a manner that was almost miracu- 
lous. The late Samuel D. Risley, famous opththalmolo- 
gist, of Philadelphia, told me that in chronic inflamma- 
tory conditions of the eye, accompanied by opacities 
and indurations, he had frequently found thyroid medi- 
cation of great value. Do not forget its use in fractures 
that are slow to unite, or of fecal fistulas that have 
failed to heal. 
I have observed that sometimes when thyroid medi- 
cation had failed, another package, put out by the same 
laboratory perhaps, would prove effective. It was very 
puzzling to me until I learned that Kendall, of the Mayo 
Research Laboratory, has found that the iodine content 
of the thyroid gland of the dog, the hog, the sheep, and 
the cow, was four or five hundred per cent greater in 
the summer months than in the colder season of the 
year. 
In undersized children, or wherever else thymus or 
adrenal medication is indicated, in addition to such 
medication, instruct your patient to eat sweetbreads 
two or three times per week; for none of the endocrine 
glands play a part of selfish isolation, hence they act 
best when combined. 
The sexual glands inhibit the thymus, as well as the 
pituitary. The pituitary in turn inhibits the thyroid 
and stimulates the gonads, while the thyroid inhibits 
the adrenals. This tangled skein of cause and effect, 
of influence and counterinfluence, of stimulation and 
inhibition, holds within its mesh the great future of 
medicine. And unto him to whom there is given an 
understanding of the laws of internal secretion, there 
shall be added all things else. 
