214 THE INTERNAL SECRETIONS—1920 
A few things the majority are agreed upon. In gen- 
eral, the total ovarian secretion tends to promote the 
excretion of calcium and the retention of phosphorus 
and it arouses activity in most, if not all, of the re- 
maining ductless glands.t The implantation of the 
fertilized ovum is assisted by, if not absolutely depen- 
dent upon, the presence or internal secretion of the 
corpus luteum. The activity of the uterus is main- 
tained and regular contractions are promoted prob- 
ably by the secretion of the interstitial cells.* 
The ovary produces at least two distinct internal se- 
cretions (some investigators believe there are more) * 
—one from the interstitial cells or stroma, and one 
from the corpora lutea. That produced by the former 
is indirectly concerned in the regulation of menstrua- 
tion and nutrition generally. The corpus luteum sen- 
sitizes the uterine mucosa’ and inhibits ovulation. It 
is also an important factor in the growth of the mam- 
mae. According to Osborne,* it is probable that one 
of the functions of the corpus luteum is to cause men- 
struation. Theoretically, its therapeutic administra- 
tion ought to be valuable in the treatment of the nausea 
and vomiting of pregnancy, since the true corpus luteum 
is only formed in pregnancy, but in routine it has failed 
to have any definite value.® In this condition adren- 
alin has been of more service than any other endocrine 
preparation. I have had some very good results with 
it. Giving ten drops of the 1-1000 solution every four 
hours frequently has succeeded when other measures 
failed. Dr. Bloomfield informs me that he and the 
other members of the staff of the Chicago Lying-In 
Hospital, including De Lee, use it almost as a routine 
measure. 
THE RELATIONS OF OTHER ENDOCRINES 
The pineal gland is supposed to be antagonistic to 
the ovary, tumors that cause destruction of it tending 
