THE FUNCTION OF THE OVARY 219 
istics. There evidently is some correlation between 
the two in normal circumstances.’ In this connection, 
Falta and Meyer" state that “those adenomata of the 
adrenal cortex that are associated with hyperfunction 
of the cortex are of great interest in the study of the 
internal secretions. There is a difference in the clin- 
ical picture according to whether they develop in the 
entirely childish or in the juvenile or the adult organ- 
ism. In the child there is an enormously accelerated 
development of the body, and premature development 
of the genitalia. The condition nearly always affects 
girls.” So marked are the consequences that it seems 
evident that the secondary sex characteristics are 
dependent largely on the adrenal cortex." 
Hypo-ovarism is a far more frequent condition than 
over activity of the ovaries. The latter may occasion- 
ally be found in early life accompanying pituitary dis- 
ease, abnormal thymus atrophy, or a pineal tumor. 
Resutling from the dyscrinism, the ovaries may func- 
tion very early or abnormally and menorrhagia or 
metrorrhagia may develop. Consequently. the adrenal 
glands, being excessively stimulated by this abnormal 
activity of the ovarian hormone, may be depleted, re- 
sulting in the long periods of adynamia and asthenia 
so commonly seen in ovarian cases.° A too rapid loss 
of ovarian secretion causes depression and melancholic 
conditions.* 
In menstruation, large amounts of calcium as well 
- as other salts, are lost; consequently, too frequent or 
profuse menstruation results in too great a loss of 
calcium and other salts and the bones, hair, teeth and 
nails may suffer; and an aggravating nervousness, 
loss of sleep and irritability follow.‘ 
Pepe‘? reports eleven cases of scanty milk secretion 
successfully treated by corpus luteum. He believes 
that there exists a hypogalactia concurrent with ovari- 
an insufficiency, in which case the homo-organotherapy 
