220 THE INTERNAL SECRETIONS—1920 
by corpus luteum or ovary serves as a regular and 
efficacious galactagogue. 
OVARIAN HYPERACTIVITY 
Hypertrophy of the ovaries is perhaps always the 
cause of precocity in girls. Piccardo’® is convinced 
that excessive function of the ovaries is directly con- 
cerned in the etiology of uterine fibromata. He sug- 
gests antagonistic organotherapy as treatment, the thy- 
roid gland being his choice. Bandler believes hyper- 
activity of the pituitary may be an underlying cause 
of fibroids. Briggs, of Sacramento, believes fibroids 
are caused by hyperactivity of the ovaries and reports 
good results from mammary therapy. 
As the mammary hormone is known to be antago- 
nistic to ovarian function, the former is valuable in 
controlling over-function of the latter. Mammary ex- 
tract is given in doses of seven to ten grains—or more 
—three times a day, for menorrhagia, metrorrhagia 
and uterine fibromata. It acts, according to Bandler,® 
particularly well when combined with anterior pitui- 
tary extract. I have had some favorable results with 
this method. Mrs. L., aged 35; periods always pain- 
ful and profuse but of the regular twenty-eight-day 
type until about her 33rd year, when the interval was 
lessened to only seventeen days and the flow became 
more profuse. The uterus was larger than normal 
and hard. Mammary gland, ten grains t.i.d., length- 
ened the interval to twenty-three days and later to 
twenty-eight, and noticeably decreased the quantity of 
the flow. 
I have tried mammary extract in several cases of 
menorrhagia, one case of fibrosis uteri and one appar- 
ently hyperovarism. The duration of the flow was 
shortened and the intervals lengthened. 
