THE ESSENTIAL DUCTLESS GLANDS 239 
development of the thorax, pelvis, and larynx, the voice 
remaining high-pitched, as in the child; the muscles 
lose their tone and the prostate and vesicula seminals 
fail to develop, the bones of the extremities, however, 
growing abnormally long.” 
Compare this symptom complex with the syndrome 
resulting from conditions where the testicles are in a 
stage of hyperfunction. We find here, as we found in 
hyperadrenia, an abnormal sexual and physical devel- 
opment; “a general growth in stature; a premature ap- 
pearance of secondary sexual characters, such as 
growth of hair on the face in the male and in the arm- 
pits, and on the pubes in both sexes; development of 
breasts and generative organs; in short, all the signs 
of puberty.” (14) 
This similarity of symptoms produced by an in- 
creased activity of the testicles and the adrenals, led 
Sajous (15) to deny to the testicles a separate internal 
secretion. He believes in the existence of ‘adrenal 
rests” or small areas of chromaffin tissue outside of the 
adrenal bodies, as in the testicles, ovaries, and pitui- 
tary, the internal secretion of which would be identical 
with that of the adrenals. 
The endocrine action of the ovaries in females is 
somewhat similar to that of the testicles in men, with 
slight modifications, however. The removal of the ova- 
ries in the young leaves the sexual organs in an unde- 
veloped state, while their removal in adults causes 
atrophy of those organs, the menopause and diminished 
sexuality. 
Space and time do not permit us to analyze the inter- 
nal secretions of any of the other organs, as the thymus, 
pineal, pancreas, spleen, etc. Besides, our knowledge 
of the nature of their hormones is still very scant. 
ORGANOTHERAPY 
There is, however, another important aspect of the 
study of the ductless glands that we may touch upon, 
