248 THE INTERNAL SECRETIONS—1920 
loss of sleep. I informed my patient that I did not think 
it wise to treat the diabetes heroically, as we might up- 
set his metabolic equilibrium, as is often done in elderly 
diabetic patients when the diet is radically changed. 
He persisted, however, in his desire for treatment, and 
it was administered with reluctance. The injections 
took place as follows: Sevtember 10th, September 
25th, October 4th, October 18th, October 27th, Novem- 
ber 7th. At this time my patient voiced the opinion 
that he was feeling ever so much better, and that his 
memory had greatly improved, so much so that he had 
written an article for a Washington paper which had 
been accepted. He then received injections on: No- 
vember 18th, November 28th, and December 15th. The 
patient was so much improved mentally that he was 
busy writing every day; his mentality was that of a 
man of forty. He was able to express himself in defi- 
nite terms, and recall past events that had happened in 
the political world years ago; sleep was undisturbed. 
He informed me that he did not become fatigued on ex- 
ertion, either physically or mentally. 
During the course of treatment his sugar output re- 
mained unchanged, although the polyuria and weakness 
disappeared. This is a remarkable case in that definite 
results were produced in a man of this age, as evidenced 
by a dismissal of all symptoms that might be referable 
to a final waning of all endocrine functioning. 
CASE II.—Young man, aged thirty-four, instrument 
maker by trade; venereal history negative. A history 
of diabetes extending back three years. Complained on 
visiting me of general weakness, loss of weight and 
ability to concentrate. Sexual instinct at a minimum; 
erection impossible. Physical examination revealed a 
prematurely old man. Skin dry with beginning wrin- 
kles; heart and lungs negative. 
First injection October 17, 1919, continued for a pe- 
riod of four months at intervals of seven days. There 
was no dietetic treatment advised, and none indulged 
in. On discharge, the patient was sugar free, had 
gained thirty pounds and, as he expressed it, was feel- 
ing like a new man. He also gained back the power of 
erection. His spermatogenic function, which had been 
absent for two years, returned gradually. His wife be- 
came pregnant in May, 1920, seven months after the 
