STERILITY AND THE ENDOCRINES 249 
patient received his first injection, but unfortunately 
miscarried at the third month. He now enjoys better 
health than at any time during the past five years, and 
is doing hard manual work without any appreciable 
fatigue. 
CASE II].—Female, married; no children. Men- 
struated at the age of fifteen. Periods remained regu- 
lar until the age of twenty-seven, usually lasting four 
or five days; no pain. At this time the patient came 
home one evening to find her cousin dead in bed. Fol- 
lowing this shock she swooned, was revived and con- 
tinued in her usual good health, but did not menstru- 
ate. She had suffered from amenorrhea ror the past 
two years, previous to consulting me. Physical exam- 
ination revealed no obstruction or malposition of the 
uterus. There was no tenderness over the ovarian area, 
nor was there any leucorrhea. Skin was slightly icteric, 
and drawn in appearance. Frontal headache was com- 
plained of. The patient presented an apathetic appear- 
ance. 
A specimen of the husband’s semen examined on a 
warm stage microscope showed very active sperma- 
tozoa. His Wassermann was negative, as was that of 
his wife. I advised routine injection of my serum. The 
patient received one injection weekly for a period of 
four months. During the middle of the fourth month 
she menstruated. I visited her the following day, and 
found that she was losing a normal amount of men- 
strual blood. The flow continued for two days and sub- 
sided. The next period was regular, and they have 
continued so to the present. This patient had been 
curetted previous to the administration of the serum, 
without result. Undoubtedly her ovarian dysfunction 
was due to the sudden shock she received over two 
years ago, and as a result her endocrine equilibrium 
was disturbed and normal stimulus did not take place. 
CASE IV.—Male, aged fifty-seven; hatter by trade. 
History elicited the fact that the patient’s skin was 
becoming dry and rough. The sexual function had been 
impaired for the past four months, with inability either 
to ejaculate or maintain erection. The patient was un- 
able, at times, to sleep more than two hours a night. 
He became uninterested in his work, lost weight and 
strength, and presented an apathetic appearance. The 
