TREATMENT OF PERNICIOUS ANEMIA 261 
It has been noted that recent cases, as compared with 
those that have existed during a comparatively longer 
period, often show more serious losses of hemoglobin 
than the more chronic cases, but usually they respond 
more readily to treatment. 
Loss of weight during the treatment is usual and 
varies, depending upon the location of the infection. 
All the gall bladder cases that have come to my atten- 
tion have lost more in weight than those in whom mouth 
and other focal infections were prominent causes. In- 
cidentally, I have noticed that those cases that lost 
weight under this treatment usually have responded 
more rapidly in the improvement of the blood picture. 
The return of the former weight is oftentimes inex- 
plicably delayed. 
The administration of the phylacogen not merely 
serves to stimulate the immunity and antagonize the 
production of the poisons which are fundamentally re- 
sponsible for the blood picture, but the peculiar lemon 
color of the skin disappears following the hypodermic 
injections of the phylacogen before much improvement 
is found in the blood picture. 
I have had most uniform results from the Mixed In- 
fection Phylacogen. Its use should be continued until 
no reaction is obtained from the injection. Some cases 
have had injections for twenty-five days each month 
for four to nine months before the immunity seemed 
to be established and the blood picture became normal. 
An occasional large dose which may be sufficient to 
cause a slight chill often is of great stimulating benefit 
after the prolonged use of this remedy. The injections 
are best made in different parts of the body, and hypo- 
dermically. 
The prospects in the treatment of pernicious anemia 
ordinarily are not at all good, and it is clear that per- 
sistence is a great factor in the treatment outlined. It 
is also necessary to supplement the removal of the foci 
