ANGIONEUROTIC EDEMA 287 
sitive to foreign proteins of any kind, either in the 
form of food or medicines, and these patients may re- 
quire desensitization by the Besredka (9) method or 
modification before biological products can be used. 
The carbohydrate intake should be carefully regulated 
in accordance with urinary findings. Of the endocrine 
products, parathyroid gland to control neuromuscular 
unbalance, and pancreas substance to reéstablish nor- 
mal work of the pancreas and antagonize the adrenals 
are directly indicated. 
Thyroidectomized horse serum, while indicated as a 
thyroid antagonist, almost invariably serves as a direct 
exciting cause of increased attacks of angioneurotic 
edema by reason of the protein-bearing serum. Thy- 
roidectin in 5-grain capsules, three times daily, is bet- 
ter borne. The following prescriptions have been used 
with success by the writer: 
RK: Quinine Hydrobromide ............... gr.v 
BEOM, ATSCHAGG ete ce once chee calcne gr. 1/10 
Atropines Sulphate ce: doc. ciee Se eo gr. 1/1000 
M. et ft. tales Caps. No. 100. 
Sig: One capsule three times daily, at meals. 
Ix: Parathyroid Gland, Desiccated............ gr. ss 
Panercas.  DesicCated sc 2. so. ws deiea clas vce gr. ij 
BilOs Salts) POW Gere”. ccc 2's os 6 s.c.0 ohriys.nt er: j 
CaleiumMewiACtaAtes + cies wn ake me ee gr. jss 
M. et ft. tales Caps. No. 100. 
Sig: Two capsules four times a day between meals. 
RESUME 
Angioneurotic edema is a pluriglandular hypersecre- 
tory syndrome, in which thyroid excess is a preliminary 
feature and adrenal hyperactivity the secondary and 
predominating characteristic. 
Local wheal formation develops because of localized 
vasodilation of thyroid origin, with prompt subsequent 
fatigue-paralysis of the irritated vasodilating nerve 
end-plates and increased vessel-wall permeability, 
whereby blood-serum oozes into the surrounding tis- 
sues; it persists through primary antagonistic vaso- 
