33*2 



in a secondary, to death of a primary seat, between which there 

 subsisted a natural relation of dependence; and that the mode was 

 that of addition of properties, in cases of secondary disease, termi- 

 nating in death, produced directly by primary disease in seats which 

 acknowledged no natural dependent relation. 



22. Those effects of primary disease which consist in modifica- 

 tion, or preternatural formation of substances, allied or related with 

 the principle of life, produce local death in or near the seat of such 

 effects, either by direct relation with the life of such seat, as when 

 a disease of a bone, perhaps a dead portion of a bone, produces or 

 maintains ulceration (which is one kind of death) of the contiguous 

 parts, or by the influence of such effects upon the circulation, as 

 when a tumour, together with the adjoining substances, sloughs from 

 an interrupted supply of blood, caused by the pressure of a foreign 

 growth ; or as when, by long processes of disease, extreme vessels 

 give way, and the life of the part becomes extinct, because the cir- 

 culation has ceased. The examples which fall under this class arc 

 not very numerous. 



23. Secondary indirect disease produces universal death by 

 influence upon the blood and circulation, upon which the existence 

 of the diffused spirit depends. Secondary, indirect, disease operates 

 by this medium in two ways: Jst, by producing secondary direct 

 disease, which to produce death is commonly related with a 

 functional organ, upon which life depends, and upon which life de- 

 pends in no other way than by the importance of this function with 

 respect to the blood; 2nd, by preventing the adequate supply of 

 blood to the whole system, with or without any mediate relation, 

 with a function or organ, subservient to the formation and circula- 

 tion of the blood. 



24. The first is illustrated in the cases of death produced by 

 occasional material disease; as when death takes place from irrita- 

 tion, as from that of a stone in the kidney, a diseased bone, &c.; 

 in these cases, these material effects of primary disease affect, 

 impair, and finally destroy the action of some functional organ, as 

 of the heart, in consequence of which universal death succeeds. 



25. The second is exemplified when death happens from the 

 pressure of a tumour upon the trachea, or when death is produced 

 by spontaneous hemorrhage, as by the bursting of an axillary, or 

 iliac aneurism. 



26. This classification includes nearly all the possible modes 

 of local, or universal death, according to the relations before 

 sketched. The inference, that disease in one seat produces univer 

 sal death by relation with a functional organ, which organ is related 

 with diffused life through the medium of the blood, is founded upon 

 the fact that a local disease never produces death until the functions 

 connected with the blood have ceased to be performed. In other 

 words, all the processes of organic life, as the spiritual assimilation, 

 the secretions, &c. do not cease until the heart has ceased to 



