HISTORICAL. 7 



They were able to produce typical amoebic dysentery 

 in cats by the injection into the rectum of pus con- 

 taining amoebae obtained from a liver abscess. 



In 1895, Celli and Fiocca commenced the pub- 

 lication of a series of papers dealing with the amoebae 

 occurring in man. They did not consider these 

 organisms of etiological significance in dysentery, 

 and their results only added to the confusion which 

 had arisen regarding the existence of pathogenic and 

 non-pathogenic species. 



In 1897, Casagrandi and Barbagallo concluded 

 that none of the amoebae found in the intestine of man 

 were pathogenic, but they separated several species 

 which will be considered in the chapter devoted to 

 classification and nomenclature. 



The later investigations of Harris, in the United 

 States, of Strong and Musgrave, and of Musgrave 

 and Clegg in the Philippines, were confirmatory of 

 the etiological importance of amoebae in the produc- 

 tion of dysentery, especially that form prevalent in 

 the tropics and accompanied by abscess of the liver. 

 These investigators jvere all successful in producing 

 dysentery in animals by material containing the 

 amoebae occurring in man. In 1902, Jiirgens pub- 

 lished a monograph upon amoebic dysentery in which 

 he differentiated a pathogenic from a non-pathogenic 

 species, calling attention to the difference in mor- 



