HISTORICAL. 5 



Shortly after the publication of the first paper of 

 Kartulis an investigation of dysentery at Prague, 

 by Hlava, resulted in the finding of amoebse in sixty 

 cases of the disease, his description of the organisms 

 agreeing with that of Kartulis. He experimented 

 upon dogs and cats by injecting feces containing 

 amoebae into the rectum, obtaining positive results 

 in two dogs out of seventeen and in four cats out 

 of six experimented upon. This paper was followed 

 by those of Massiutin and Pfeiffer, who both found 

 amoeba3 in the feces in cases of dysentery. 



In America the first investigator to observe 

 amoeba? in a dysentery case was Osier who, in 1890, 

 in a patient suffering from chronic dysentery com- 

 plicated by liver abscess found amoebge in the stools 

 which answered in their morphology to those de- 

 scribed by Kartulis. His observation was followed 

 in the same year by those of Musser and Stengel, and 

 in 1891, by those of Dock, who confirmed the pres- 

 ence of these organisms in dysenteric stools. 



In 1891, Councilman and Lafleur published their 

 classical monograph upon amoebic dysentery, in which 

 they concluded that the disease is a clinical entity and 

 is characterized by definite pathological lesions due 

 to the amoebae. Their study was based upon fourteen 

 cases of amoebic dysentery, and besides giving a most 

 excellent description of the parasite now known as 



